Program

Jackson Square2

Tuesday, October 11, 2016
3:00-9:00 PM REGISTRATION- 12th Floor Westin Hotel
7:00-9:00PM WELCOME RECEPTION – River 127 Restaurant, The Westin New Orleans, Canal Place
Wednesday, October 12, 2016
7:00AM-5:00PM Registration – Foyer II
7:00AM – 5:00PM Platform Speaker Slide Preview – Cotton Room
7:00-8:00AM Light Continental Breakfast – Foyer II
8:00-8:15AM OPENING REMARKS – Grand Ballroom
Lee Hamm III, MD, FACP, Dean of the Tulane School of Medicine
8:15-8:20AM Keynote Speaker Introduction – Grand Ballroom
Marcelo Kuroda, PhD, Conference Chair
Introduction of Keynote Speaker
Joseph Michael McCune, MD, PhD,
University of California San Francisco
8:20-9:00AM Keynote Address
Exploration of Lentiviral Pathogenesis and Treatment in vivo
Joseph Michael McCune, MD, PhD
Session I – Macrophages and AIDS Pathogenesis
Chairs Kenneth Williams, PhD – Boston College
Namita Rout, PhD – TNPRC, Division of Immunology
9:00-9:30AM Chair Presentation Kenneth Williams, PhD
9:30-9:45AM Long term efficient control of SIV infection in macaques is associated with an intact intestinal barrier Maria Daskalaki
9:45-10:00AM Intestinal dendritic cells and macrophages differentially affect HIV-1 transmission across the intestinal mucosa Mariangela Cavarelli
10:00-10:15AM Gut macrophages that accumulate inprogressive SIV infection are poorly phagocytic and non-inflammatory Simon Barratt-Boyes
10:15-10:30AM Liver associated inflammation and macrophage infiltration during partly reversed duuring cART Bridget Fisher
10:30-11:00AM BREAK Morning break
11:00-11:15AM Direct targeting of macrophages with methylglyoxal-Bis-Guanythydrazone decreases SIV-associated cardiovascular infllamation and pathology Joshua  A. Walker, McGrath, Kenneth C. Williams
11:15-11:30AM Expression and phosphorylation of SAMHD increases with viral loads in the brains of SIV-infected rhesus macauqes Woong-Ki Kim
11:30-11:45AM SIV sequences in the choroid plexus represent CNS viral reservoirs in rhesus macques that develop AIDS with SIVE Jaclyn Mallard
11:45AM-12:00PM Evidence that Long-Lived Macrophages Are an Important SIV Reservoir in the Rhesus Macaque Model of AIDS Marcelo Kuroda
12:00-1:30PM BREAK LUNCH on your own
12:00-5:00PM Poster Set up – Terrace and River Rooms
Session II – Cure, Latency and Reservoirs
Chairs Steven Deeks, MD – UCSF School of Medicine
Steven Braun, PhD – TNPRC, Division of Regenerative Medicine
1:30-2:00PM Chair Presentation Steven Deeks, MD
2:00-2:15PM NK cell accumulation in lymph node follicles during non pathogeneic SIV infection Nicolas Huot
2:15-2:30PM The IL-15 superagonist ALT-803 decreases plasma viral loads in rhesus macaques in the absence of antiretroviral therapy thruogh host immunomodulation Amy Ellis-Connell
2:30-2:45PM The human IL-15 superagonist ALT-803 activates NK cells, memory T cells and latently SIV-infected CD4+ cells in the macaque model of HIV Gabriela Webb
2:45-3:00PM FTY720 administration during ART-reatment targets cytooytic CD8+ T cells to lymphoid sites of HIV persistence Sara Paganini
3:00-3:15PM BREAK Afternoon break
3:15-3:30PM Special Issue of the Journal of Medical Primatology Presentation Ronald Veazey
3:30-3:45PM Gene and protein signature of in vivo SIV-infected cells Diane  L. Bolton
3:45-4:00PM Efficient inactivation of SIV replication with specific RNA-guided Cas9 nucleases and nickases Lisa M. Smith
4:00-4:15PM A nonhuman primate model of fully MHC-matched allogeneic stem cell transplantation to study HIV reservoir clearance Jonah Sacha
4:15-4:30PM Repeated TLR7 agonist treatment of SIV infected macaques on ART can lead to viral remission James Whitney
4:30-4:45PM Heterodimeric IL-15 induces effector CD8+ T cell activation and trafficking to the gerimnal centers of SIV infection macaques Antonio Valentin
4:45-5:00PM Macrophage persistence in adipose tissue of rhesus macaques Marissa Fahlberg
6:00-9:00PM POSTER RECEPTION – Terrace and River Rooms
Thursday, October 13, 2016
7:00 AM – 5:00 PM Registration – Foyer II
7:00 AM – 4:00 PM Vendor Display – Foyer I
7:00 AM – 5:00 PM Platform Speaker Slide Preview – Cotton Room
7:30 – 8:30 AM Light Continental Breakfast – Foyer II
Session III – Immunity and the Microbiome
Chairs Skip Virgin, MD, PhD – Washington University School of Medicine
Nicholas Maness, PhD – TNPRC, Division of Microbiology
8:30-9:00AM Chair Presentation – Skip Virgin, MD, PhD
9:00-9:15AM Rhesus Macaque CD161+CD8+ T Cells Represent Mucosal Tissue Homing T Cell Subsets
with Th1/Th17 Type Cytokine and Cytotoxic Potential
Namita Rout
9:15-9:30AM Dynamics and differentiation of Tfh lymph nodes of SIV-infected rhesus macaques: role in viral persistence Felicien Moukanbi
9:30-9:45AM MR1 restricted mucosal associated invariant T cells respond to mycobacterial vaccination and infection in nonhuman primates Justin Greene
9:45-10:00AM Heterogeneity in peripheral blood and mucosal INKT function has implications for their role in maintenance of mucosal immunity in AIDS pathogenesis Nell G. Bond
10:00-10:15AM Mucin-binding IgG: characterizing a novel antibody effector function and discovery of a new Fc receptor Jeffrey Schneider
10:15-10:45AM BREAK Morning break
10:45-11:00AM Influence of neutralizing antibody resistance of SIV on subsequent disease progression in macaques Fan Wu
11:00-11:15AM Cannulation of the thoracic duct in rhesus macaques: a proof of concept study to investigate lymph fluid immunology Irene Bukh Brody
11:15-11:30AM Gut microbiome and immunce activation in mucosal SHIV transmission Yongjun Sui
11:30AM-1:00PM BREAK Lunch on your own
Session IV – Prevention: Vaccines and Microbicides
Co-Chairs James Hoxie, MD – University of Pennsylvania
Bapi Pahar, DVM, PhD – TNPRC, Division of Comparative Pathology
1:00-1:30PM Chair Presentation James Hoxie, MD
1:30-1:45PM Identifying early targets of SIV in the rectal mucosa of rhesus macaques Natelle Greco
1:45-2:00PM Accelerated development of mature germinal centers in rhesus macaques following infection with non CD4 tropic variant of SIVmac239 Kartika Padhan
2:00-2:15PM Direct probing of germinal center responses reveals immunological correlates for nAb responses to an engineered HIV trimer Collin Havenar-Daughton
2:15-2:30PM Molecular patterns of SHIV env-ab co-evolution in rhesus macaques recapitulate HIV-1 env-ab Co-evolution in humans infected by HIV-1 strains bearing homologous envs Hui Li
2:30-2:45PM BREAK Afternoon break
2:45-3:00PM Acute induction of CXCR4+GC Tbh cells is associated with protective outcomes in SIV infected rhesus macaques Smita S. Iyer
3:00-3:15PM MPER-specific antibodies readily detected in SIV-infected rhesus macaques Rosemarie Mason
3:15-3:30PM Induction of CXCR5+ follicular CD8 T cells by CD40L adjuvanted Clade C DNA/MVA SHIV vaccine Vijayakumar Velu
3:30-3:45PM Combining vaccine strategies to induce durable and high magnitude SIV gag specific CD8+ T cells and HIV-1 envelope specific antibody responses in rhesus macaques Caroline Petitdemange
3:45-4:00PM Novel pDNA prime-boost vaccine strategy combining Gag and Env elicits broad cytotoxic T cells and antibody respones targeting conserved subdominant gag and env epitopes of HIV and SIV Xintao Hu
4:00-4:15PM Single-cycle adenovirus (SC-Ad) as antigen gene amplifying vaccines vs. HIV-1 William E. Matchett
4:15-4:30PM Evolution of T cell responses to RhCMV-vectored SIV vaccine in young wild-type RhCMV-negative and -positive macaques Kawthar Machmach Kesmy
5:00-10:00PM Cocktail Reception and Banquet at the WWII Museum
Friday, October 14, 2016
Session V – Virus-Host Interactions and Genomics
Chairs Thomas Hope, PhD – Northwestern University School of Medicine
Mahesh Mohan, DVM, PhD – TNPRC, Division of Comparative Pathology
8:00-8:30AM Chair Presentation Thomas Hope , PhD
8:30-8:45AM Mechanisms of natural resistance of baboons to SIV infection Veronica Obregon-Perko
8:45-9:00AM Mauritian cynomolgus macaques with M3-M4 MHC genotype control SIVmac251 infection Hongzhao Li
9:00-9:15AM Simian immunodeficiency virus infection of KIR- and MHC class I-defined rhesus macaques Moritz Ries
9:15-9:30AM Investigating cross-species transmissions of SIVcpz to humans using humanized-BLT mice Zhe Yuan
9:30-9:45AM BREAK Morning break
9:45-10:00AM Sustained B-cell responses correlate with nuetralizing antibody induction in SIVmac239 infection Hiroyuki Yamamoto
10:00-10:15AM A single amino acid in HIV-1 env can influence species tropism Theodora Hatziioannou
10:15-10:30AM Transcriptome analysis of differentially expressed ISG subsets in acute and chronic phase of pathogenic SIV infection suggests both type one and type two interferons contribute to persistent ISG expression and synergize to anti-viral functions Nadia Echebli
10:30-10:45AM Vascular related pulmonary pathology in Indian rhesus macques experimentally co-infected with Mycobacterium Tuberculosis and simian immunodeficiency virus Denae N. LoBato
LATE BREAKER ABSTRACTS
10:45-11:00AM Efficacy of epithelial stem cell-based vaccine to induce mucosal immune responses and protect against repeated low dose SIV challenge Marie-Claire Gauduin
11:00-11:15AM Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes Sean P. O’Brien
11:15-11:30AM Pre-inoculation infusion with hyperimmune globulin protects against vertical transmission in the rhesus macaque model of congenital CMV infection Amitinder Kaur
11:30AM-12:00PM Closing Remarks and Preview of Upcoming Symposium
Marcelo Kuroda, PhD, Conference Chair
TNPRC, Division of Immunology
Shelby O’Connor, PhD, 2017 Conference Chair
Wisconsin National Primate Research Center

Hosted by:
Tulane National Primate Research Center
Tulane University

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Questions?
NHP2016@wave.tulane.edu or cme@tulane.edu
985‐871-6565 or 504-988-5466

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